CHOP方案治疗复发性非何杰金氏淋巴瘤38例近期疗效分析

Treatment of Recurrent Non-Hodgkin's Lymphoma(NHL)With CHOP Regimen-Observation of the Short-term Curative Effect in 38 Cases

本文报道CHOP方案治疗38例复发性非何杰金氏淋巴瘤（NHL）的结果，全部病例均经病理组织学证实。按成都会议方案属中、高度恶性者78．9％，Ⅲ、Ⅳ期病人占65．8％。均经CHOP方案化疗4～11疗程，6疗程以上者占71％，8例加用其它一些抗癌药，9例化疗后予以放疗或手术切除。全组总的缓解率71％，完全缓解率31％，中位缓解期10．3个月。主要毒副反应为消化道反应、白细胞减少及脱发，一般病人都可耐受。作者认为，CHOP方案是一个安全有效的化疗方案，可用于复发性NHL的治疗。

The results of chemotherapy with CHOP regimen in 38 recurrent patients of NHL, all pathologically confirmed, were reported. 78. 9% of the cases were median-grade or high-grade malignant lymphoma according to Chendo meet's classifications schedule NHL conducted classification (1985), 65. 8% of the cases at Ⅲ，Ⅳ stage. The therapy time for the patients treated by CHOP regimen were 4～11 courses, 70% of the cases over 6 courses. All patients were treated by CHOP regimen, 8 cases also applied the other anticarcinogenic drugs, and 9 cases underwent adjuvant radiotherapy or surgient therapy to the residual disease following chemotherapy. The result for the whole group, total response rate was 71 %, completed remission rate 31%, and MTS 10.3M. The main side effects including gastrointestinal toxicity, leucopenia and alopecia were not serve. The authors believe that CHOP is a safe, effective regimen for the patients with relaped case of NHL.