灵芝孢子粉胶囊急性毒性及遗传毒性实验研究

Study on acute toxicity and genetic toxicity test of Ganoderma Lucidum Spore Powder Capsule

目的:了解灵芝孢子粉胶囊的毒理学,评价其安全性。方法:小鼠急性毒性试验和遗传毒性试验(Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验)。结果与结论:灵芝孢子粉胶囊的小鼠经口LD50>10 g/kg;在Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验中均呈阴性反应,未显示有遗传毒性作用,表明灵芝孢子粉胶囊基本无毒性。

OBJECT To evaluate the toxicological security of Ganoderma Lucidum Spore Powder Capsule. METHODS Acute toxicity test and genetic toxicity test （ Ames test.Micronucleus test of bone marrow cell in mice and sperm shape abnormality test in mice） were made. RESULTS and CONCLUSION The results showed that LD50（ per os ） was higher than 10 g/kg; Ames test, Micronucleus test of bone marrow cell in mice and sperm shape abnormality test in mice appear negative reaction and a lack of toxic effect, indicating that Ganoderma Lucidum Spore Powder Capsule is non - toxicity.