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白念珠菌RIM101途径与环境pH的应答反应 被引量：5

The response to environmental pH of RIM101 pathway in Candida albicans
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摘要 白念珠菌(Candida albicans)是一种重要条件致病菌,近年来引起人们的关注,大量的研究由此展开。对环境的改变积极做出应答是白念珠菌致病的重要条件。外界环境尤其是pH的变化影响着白念珠菌的形态和毒力。RIM101途经是真菌中一种保守的信号转导途径,白念珠菌也存在RIM101途经,并且该途径至少部分地控制着细胞对pH的应答。这里主要综述了近年来有关白念珠菌RIM101途径、pH应答及两者相互关系的研究。 Candida albicans is the most common kind of human opportunistic pathogen and gets many attentions in recent years. A lot of research has been done. The sites this organism colonizes differ in pH. C. albicans must be able to response to the environmental changes for its survival and pathogenicity. Extracellular environment, especially pH changes, is critical for C. albicans morphological differentiation and virulence. RIM101 pathway is a conserved fungal signal transduction pathway and at least partly controls the cellular pH response through the activity of the zinc finger transcription factor Rim101p. This review concisely summarized recent research on RIM101 pathway, pH response and their relationship in C. albicans.
作者 李明春 梁勇 魏东盛 邢来君
机构地区 南开大学微生物学系天津市微生物功能基因组学重点实验室
出处 《微生物学报》 CAS CSCD 北大核心 2007年第2期366-369,共4页 Acta Microbiologica Sinica
基金 国家自然科学基金(30570096) 教育部留学回国人员科研启动基金[教外司留(2005)546号]~~
关键词 白念珠菌 RIM101途经 pH应答 Rim101p Candida albicans RIM101 pathway pH response Rim101p
分类号 R379 [医药卫生—病原生物学]
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参考文献27

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同被引文献54

  • 1李艳琴,孙永艳.可用于基因检测的啤酒发酵液DNA提取方法研究[J].食品科学,2007,28(3):191-194. 被引量：6
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  • 7Philpott CC. Iron uptake in fungi: a system for every source. Biochim Biophys Acta, 2006, 1763(7) : 636-645.
  • 8De Freitas J, Wintz H, Kim JH, et al. Yeast, a model organism for iron and copper metabolism studies. Biometals, 2003, 16 ( 1 ) : 185-197.
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微生物学报
2007年 第2期

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