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乳癌病人单次卡铂和阿霉素化疗诱发的染色体损伤和细胞生物学毒性 被引量:2

Chromosome damage and cytobiologic toxicity induced by carboplatin and adriamycin in treatment of breast cancer
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摘要 应用常规染色体畸变分析和胞浆分裂阻滞微核(cytokinesisblockmicronuclei,CBMN)法对10例接受单次卡铂(平均剂量为462.9mg/m2)和单次阿霉素(平均剂量为48.1mg/m2)化疗的乳癌病人血样进行了淋巴细胞染色体畸变(chromosomeaberation,CA)和微核(micronuclei,MN)的观察分析,并通过有丝分裂指数(mitoticindex,MI)及核分裂指数(nucleardivisionindex,NDI)观测了细胞毒性。结果表明,单次卡铂和阿霉素化疗均引起了CA和MN显著性增加,所观察到的CA主要为单体畸变,其中单体间隙(chromatidgap,ctg)的增加最为显著,染色体型畸变未见显著性变化;卡铂引起MI明显减低,阿霉素对MI的影响不显著;两种化疗药物均未对NDI产生显著性影响;通过MI及NDI测量的细胞毒性之间显著性相关,但CA分析和CBMN法测得的染色体损伤之间缺乏相关性。 Blood samples of ten breast cancer patients, who received chemotherapy with single dose of carboplatin (462.9 mg/m 2) and adriamycin (48.1 mg/m 2), were analyzed by chromosome aberration (CA) analysis, cytokinesis block micronuclei (CBMN) method, mitotic index (MI) and nuclear division index (NDI) determination. The results showed that the numbers of CA and micronuclei in them significantly increased. Chromatid aberrations turning into main chromosome aberration type and frequency of chromatid gap (ctg) were significantly increased as compared with those before chemotherapy. However, frequency of chromosome type aberration was not significantly enhanced. Decreased MI was found in patients who received carboplatin treatment and no significant effect on MI was shown in adriamycin treated patients. Effects of both chemotherapeutic drugs on NDI were undetectable. There was a significant correlation between MI and NDI. No correlation was found between the data of CA and CBMN.
出处 《军事医学科学院院刊》 CSCD 北大核心 1997年第1期34-38,共5页 Bulletin of the Academy of Military Medical Sciences
关键词 乳腺肿瘤 卡铂 阿霉素 染色体畸变 微核实验 breast neoplasms carboplatin adriamycin chromosome aberrations micronucleus tests
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参考文献2

  • 1蒋本荣,中华放射医学与防护杂志,1991年,11卷,168页
  • 2金璀珍,核安全法规专题报告,1989年

同被引文献27

  • 1王利利,涂,周菊英,崔凤梅,徐晓婷.放疗对肿瘤患者外周血淋巴细胞hprt基因位点的影响[J].中华放射医学与防护杂志,2004,24(3):204-206. 被引量:6
  • 2Rice SC,Vacek P,Homans AH,Messier T,Genotoxicity of therapeutic intervention in children with aute lymphocytic leukemia[J].Cancer Res,2004,;64(13):4464-4471.
  • 3Vega-Sromberg T.Cemotherapy induced secondary malignancies[J].J Infus Nurs,2003,26(6):353-361.
  • 4Pui CH,Relling MV.Topoisomerase inhibitor related acute myeloid leukaemia[J].Br J Haematol,2000,109(1):13-23.
  • 5Koishi S,Kubota N,Sawada M,et al.Biomarkers in long survivor of pediatric acute lymphoblastic leukemia patients:late effects of cancer chemotherapy[J].Mutat Res,1998,422:213-222.
  • 6Silva LM,Takahashi CS,Carrara HHA.Study of chromodome damage in patients with breast cancer treated by two antineoplastic treatments[J].Teratogesis Carcinognesis Mutagenesis,2002,22:257-262.
  • 7Elsendoorn TJ,Weijl NI,Mithou S,et al.Chemotherapy induced chromosomal damage in peripheral blood lymphocytes of cancer patents supplemented with antioxidants of placebo[J].Mutat Res,2001,498:145-158.
  • 8Gillian M,Janer H,Willian G,et al.The quantitation of sister chromatid exchanges in lymphocytes of cancer patients at intervals after cytotoxic chemotherapy[J].Em J Cancer Clin Oncol,1983,19:1509-1515.
  • 9Duffaud F,Orsiere T,Villani P,et al.Comparison between micronucleated lymphocyte rates observed in healthy subjects and cancer patints[J].Mutagenesis,1997,12(4):227-231.
  • 10Richard F,Branda J,Patrick O' Neill,et al Factors influencing mutation at the hprt locus in T-lymphocytes:women treated for breast cancer[J].Cancer Res,1991,51:6603-6607.

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