白色海绵痣之脱落细胞分析

White sponge nevus: analysis of the exfoliated cells

从一患病家系中选8位白色海绵痣患者,取有颊粘膜典型病损处脱落细胞作光镜与透射电镜分析。涂片显示堆积于粘膜表面之白色损害系大量不全角化细胞,形态不规则,胞浆突较多、胞浆内含嗜伊红致密团块,与组织切片中主要特征相似。电镜下表现以细胞内张力细丝成分显著增多为主,膜被颗粒及细胞间镶嵌结构明显增多。提示患处上皮角化活跃但正常脱屑过程受阻。

Eight patients with white sponge nevus were selected from an affected family. The exfoliated cells of the typical affected parts on right buccal mucosa were scraped out for light microscopic and ultrastructural analysis . The smears showed that the white surface lesions of the buccal mucosa are made up of a lot of parakeratosis cells which are of irregular shapes and contain more cytoplasm processes. There are also dense eosinophilic spots in the cytoplasm of some cells. These features are similar to the main features of the tissue slices. The main features of the ultrastructural cytology include the increasing of tonofilaments and Odland's bodies in the cytoplasm of some cells,in some cases,the increasing of the inter-cellular inlay structures were also found. The results suggested that there are active keratinization but inhibited exfoliation in the course of the epithelium development.