摘要
14-3-3蛋白是高度保守的可溶性酸性蛋白家族,近年的研究表明,它们在细胞有丝分裂、生长、分化、增殖和死亡等过程中起重要的调控作用。其中14-3-3σ主要存在于上皮细胞,具有组织特异性,可以与细胞内多种信号蛋白相互作用,促进DNA损伤后的细胞周期G2期阻滞,调控细胞的生长、分化和增殖等多种生物学功能,在肿瘤发生发展过程中表达异常,可能由p53突变或启动子CpG岛超甲基化引起,与人类恶性肿瘤的发生发展及预后密切相关。该文作者仅就14-3-3σ蛋白在人类恶性肿瘤中的研究进展作一综述。
14-3-3 protein is a highly conserved soluble acid family. Recent researches suggest that they play critical regulatory roles in cellular processes such as cellular mitosis, growth, differentiation, proliferation and death, etc. 14-3-3sigma protein, one member of the family, expresses mainly in epithelial cells and has histological specificity. 14-3-3sigma protein interacts with several signal transduction proteins, induces cell cycle arrest in G2 phase after DNA damage, and regulates cellular biological functions. Abnormal expression of 14-3-3σ sigma protein is common during tumor transformation, which may be induced by p53 mutation or CpG island hypermethylation of promoter. It is closely related with the transformation, progress and prognosis of human malignant tumors.
出处
《医学研究生学报》
CAS
2007年第4期419-422,共4页
Journal of Medical Postgraduates
基金
江苏省自然科学基金资助项目(批准号:BK2003074)
