邵阳市区成人胆石症患病率及其危险因素流行病学调查

Epidemiological survey of prevalence of cholelithiasis and its risk factors in a general adult population of Shaoyang

目的明确邵阳市区成人胆石症的患病率及其主要危险因素。方法通过多阶段随机抽样,对邵阳市3个城区26个社区18岁以上居民进行调查,内容涉及问卷调查、体格检查、生化检测及肝胆B超检查。结果5267名成人完成调查,占邵阳市区总人口的1.24%。其中男性2704名,女性2563名,年龄46.1±14.4岁。B超共检出胆石症388例,占7.4%,年龄≥70岁组最高,女性患病率为男性的1.14倍。胆石症组的年龄、收缩压、体重指数(BMI)、空腹血糖和低密度脂蛋白胆固醇(LDL-ch)、糖尿病、血脂异常和脂肪肝患病率等显著高于对照组。多元回归分析显示:体重指数、年龄、脂肪肝等三项指标与胆石症密切相关。结论邵阳市区成人胆石症患病率高,体重指数、年龄、脂肪肝与胆石症密切相关。

Objective To investigate the prevalence and major risk factors of cholelithiasis among adult residents in Shaoyang. Methods A cross -sectional survey with multiple-stage stratified cluster and randomized sampling was performed. All residents aged 18 and above were invited to participate in the survey. The participants came from 26 communities of Daxing District, Shuangqing District and Beita District. Questionnaire, physical examination, biochemistry test and ultrasonography of the liver and gallbladder were undertaken. Analysis of date was performed through SPSS 13,0 for Windows statistical package. Results A total of 5,267 residents took part in the survey, which was 87.8% of adult residents of the investigated communities and 1.24% of Shaoyang municipal residents. Of the 5,276, 2,704 were males and 2,563 were females. The mean age of the participants was 46.1 ± 14.4 years. Cholelithiasis was detected with ultrasound examination in 388 participants （7.4%）. The prevalence of cholelithiasis in the group aged 70 and above was the highest. The mean age, systolic blood pressure, body mass index （BMI）, fasting blood sugar, low density lipoprotein cholesterol （LDL-ch）, and the presence of diabetes mellitus, dyslipidemia and fatty liver in the cholelithiasis group was significantly higher than those in the group without cholelithiasis （all P 〈 0.05）. Logistic regression analysis demonstrated that the prevalence of cholelithiasis was positively correlated to three risk factors, including body mass index, age and fatty liver. Conclussions There is a high prevalence of cholelithiasis among adult residents in Shaoyang. BMI, age and fatty liver are closely associated with cholelithiasis.