GBV-C/HGV在血清学非甲～戊型急性肝炎发生中的作用

Influence of GBV-C/HGV on the etiology of acute non A～E hepatitis

探讨GBV-C/HGV在血清学非甲～戊型急性肝炎发生中的作用及临床意义.采用免疫组化方法对56例血清学非甲～戊型急性肝炎患者肝组织标本进行GBV-C/HGV NS5抗原的检测,结合临床资料进行分析.血清学非甲～戊型急性肝炎肝组织中GBV-C/HGV NS5抗原检出率为53.6%,主要是以和HBV/HCV重叠感染的形式存在,重叠感染组的ALT升高和HBV/HCV感染组差异无显著意义.单纯GBV-C/HGV感染占16.1%,所引起的血清ALT升高明显低于HBV/HCV感染,而与病原不明病例差异无显著意义.GBV-C/HGV可能没有致病性或者有弱致病性,不是血清学非甲～戊型急性肝炎的主要致病因子.

To investigate the role of GB virus C/hepatitis G virus （GBV -C/HGV） on the etiology of acute non A -E hepatitis. Liver biopsy from 56 patients with acute non A - E hepatitis were detected for GBV - C/HGV non - structure 5 antigen （ NS5 Ag） by immunohistochemistry. The pathological results and the clinical data were analyzed. In acute non A - E hepatitis, the total positive rate of GBV - C/HGV NS5 Ag in liver tissues was 53.6%. The majority were coinfected with HBV or HCV. The liver function test （ALT） in acute hepatitis B or C was similar in patients coinfected and in those not coinfected with GBV - C/HGV. Only 16. 1% were infected with GBV - C/HGV alone. The ALT were significantly lower in the patients with GBV - C/HGV infected alone than those with HBV or HCV co infected, but similar to those in acute hepatitis of unknown etiology. The pathogenicity of GBV - C/HGV is doubtful. GBV - C/HGV may not be one of the main pathogenic agents of acute hepatitis.