甘草酸类药物治疗自身免疫性肝炎疗效分析

The analysis of efficacy of glycyrrhizin therapy for autoimmune hepatitis

探讨甘草酸类药物治疗自身免疫性肝炎(AIH)的疗效。应用甘草酸单胺组、甘草酸二胺组和复方甘草甜素组治疗79例AIH患者,并与糖皮质激素治疗AIH 21例患者作比较,观察其肝功能的变化,评价其疗效。3组甘草酸类药物治疗AIH可明显降低ALT,AST,TB il,DB il水平,分别获得78.2%、81.6%和82.7%的完全应答率,与激素治疗组的完全应答率(83.3%)比较,差异无显著性(P>0.05);两类药物治疗Ⅰ、Ⅲ型AIH的疗效高于Ⅱ型AIH。甘草酸类药物治疗AIH可获得与激素相同的近期疗效,但其长期疗效尚待进一步评价。

To investigate efficacy of glycyrrhizin therapy for autoimmune hepatitis （AIH）. We analyzed the levels of liver function and efficacy after glycyrrhizin therapy （ including monoammonium glycrrhizinate, diammonium glycyrrihizinate and compound glycyrrhizin） for 79 cases with AIH retrospectively. 21 cases treated with corticosteroid served as control. After treatment, the level of ALT, AST and TBil descended markedly in all of the four groups （ P 〈 0. 05. The complete responder rate in the glycyrrhizin groups and corticosteroid group was 78. 2% ,81.6% ,82. 7% and 83.3% respectively. There was no significant deference between the four groups. The efficacy rate of Type Ⅰ and Ⅲ AIH in two groups were higher than that of Type Ⅱ AIH （P 〈0. 05 ）, Glycyrrhizin therapy for autoimmune hepatitis has the similar shortternm efficacy as comcosteroid. But the longer - term efficacy of dycyrrhizin therapy for autommune hepatitis need further evaluated.