双交联琼脂包嵌凹凸棒吸附剂的制备和性能研究

Preparation and Studies of the Adsorbent Double Cross-linked Agar Beads Entrapped Attapulgite Clay

报道了一种可用于血液净化的新材料——双交联琼脂包嵌凹凸棒吸附剂(DCAA)的制备方法,并对其进行了初步的性能考查。用甲苯2,4-二异氰酸酯对已用环氧氯丙烷交联过的琼脂包嵌凹凸棒(CAA)再次交联,得到的DCAA比CAA对亚甲蓝等阳离子药物的选择性吸附性能提高约4倍,强度提高约6倍,外观更加紧密。与血液充分接触1 h,血液有形成分白细胞的损失<1％,红细胞的损失<5％,血小板的损失<8％;与血液充分接触2 h,血液中白细胞的损失<2％,红细胞的损失<10％,血小板的损失<20％。

A method for preparing the double cross-linked agar beads entrapped attapulgite clay for hemopurification is reported. Attapulgite clay was coated with agar and cross-linked by epichlorohydrin. After the process of ＂drying-out＂, the cross-linked agar beads entrapped attapulgite clay （CAA） was cross-linked again by 10% toluene 2,4,-diisocyanate in acetone at 35℃ for 3 h and 30 min. The products withstood autoclaving at 121℃ for 30 rain. The performance tests showed that the adsorption of the double cross-linked agar beads entrapped attapulgite clay （DCAA）on methylene blue was about 4 times the adsorption of CAA on methylene blue. The intensity of DCAA was raised 6 times, and the appearance of DCAA was denser. Investigation on the blood being in contact with DCAA showed ：at 1 h of contact, the loss of leucocyte was 〈 1%, of erythrocyte〈5%, and of blood platelets 〈8%; at 2h of contact, the loss of leucocyte was 〈2%, of erythrocyte 〈10%, and of blood platelets 〈20%.