基因芯片在心血管外科实验研究中的应用

Utility of Gene Chip in Study of Experimental Research inCardiovascular Surgery

生物芯片技术自20世纪90年代出现以来,已在基因测序、基因突变及多态性分析、基因表达及功能分析、文库筛选、新药开发以及病原体检测等方面进行了应用和探讨。1999年基因芯片技术应用于心血管系统的研究,在心血管外科及其相关领域,基因芯片技术的应用还不是很普遍。综述近几年基因芯片技术在心血管外科实验研究中应用的文献,观察其应用价值,介绍基因芯片在心血管外科的研究进展,对其主要内容简要总结、分析。基因芯片在心血管外科相关领域的成功应用,短时间、大范围地揭示了许多未知领域。基因芯片技术可更多地应用于心血管外科领域,可能为此领域的科研提供线索。

Gene chip technology has successfully been used in the investigation of a diverse array of heart disease as well as other human diseases. It has been used in gene sequence, gene mutation, functional analyses, screening assay, new medicine development and detection of pathogens since 1990. Gene chip technology has been used in cardiovascular disease since 1999. But by now, it has been not used commonly in cardiovascular surgery research. Summarizing the application of gene chip in experimental research of cardiovascular surgery in this paper. Assessing its values and reviewing research progress of cardiovascular surgery. The main ideas of these articles were summarized and analyzed. The successful application of gene chip in the area of cardiovascular surgery revealed lots of unknown things. Gene chip should be used in the area of cardiovascular surgery more and more. It may provide clues and point out directions for the area.