从系统生物学到配伍西药:中药现代化的一个核心战略

Formula Western Drug Maybe One of Final Strategic Aims of Modernization of Traditional Chinese Medicine

国际范围内系统生物学的兴起和发展在为中药现代化发展提供机遇的同时,更容易为西药的创新研发提供方便的手段,因为西药在分子水平上的研究基础比中药要强大得多。系统生物学对分子网络包括基因网络的深层把握将自动把西药的设计引向配伍的道路,而配伍西药可能就是中药现代化的一个终极目标。所以说中药现代化其实面临着潜在的巨大危机。如何化不利形势为有利形势,需要中药现代化的决策部门在战略战术上提出及时的应对方案。需要从国家利益的角度吸纳不同领域的研究力量并在分子水平上极大地拓展相关研究,不失时机地开展与西药配伍潜势相结合的具体研究。

Systems Biology including Systems Biomedicine is emerging internationally and providing opportunities for revolutions of Traditional Chinese Medicine （ TCM ） and conventional western drugs （ WD）, while the latter has been taking more advantages because WD has much stronger research basis at molecular levels than TCM. Thorough understanding of molecular network including gene network would automatically induces design of WD into formula western drugs equipped with TCM philosophy, but such molecular formula drug is eventually one of the final aims of modernization of TCM. So TCM is facing big threats it never met. This situation requires a nationwide and international strategy with intelligence and resolution.