声带厚度及声带癌侵犯组织深度的初步探讨

Preliminary observation on the association of thickness of vocal cords with the depth of early glottic carcinoma infiltration

目的分析声带厚度与早期声带癌侵犯组织深度的相关性。方法早期声带癌标本20例,分别制备冰冻切片和石蜡切片;手术切除的声带标本10例,制备石蜡切片。显微镜下,分别以测微尺对声带厚度和声带癌侵犯声带组织的深度进行精确测量,然后比较分析其相关性。结果声带厚度为5.32±0.84mm。早期声带癌侵犯组织的深度,在T1期冰冻切片为1.62±0.51mm,石蜡切片为1.32±0.49mm;T2期冰冻切片为2.89±0.68mm,石蜡切片为2.58±0.67mm。结论声带厚度及早期声带癌侵犯声带组织深度的定量分析,对准确实施微创治疗具有参考价值。

Objective To investigate the relationship between the thickness of vocal cords with the depth of early glottic carcinoma infiltrating. Methods Included in this study were 10 samples of vocal cord and 20 ones of early glottic carcinoma taken from operation respectively. The samples of vocal cord were embedded in paraffm for sections making and those of early glottic carcinoma were made sections by both paraffin embedding and frozen preparing procedures respectively. Then, exact measurement was undertaken to determine the thickness of vocal cords and the depth of early glottic carcinoma infiltration in the vocal tissues respeetively under micrometer microscope, and followed was a correlation analysis on the collected data in a comparative way. Results The thickness of vocal cords was 5.32 ± 0.84mm, while the infiltrating depth of early glottic carcinoma in vocal tissues were basically depended upon either the clinical staging of lesion or the section preparing procedures, with the infiltrating depth of T1 lesion being 1.62 ± 0.51mm and 1.32 ± 0. 49mm and that of T2 lesion being 2.89 ± 0.68mm and 2.58 ± 0.67mm in frozen sections and in paraffin ones respectively. Conclusion Quantitative analysis on the thickness of vocal cords and the depth of earlyglottic carcinoma infiltrating is very valuable for minimal invasive surgery performed on this kind of laryngeal lesion in clinic.