前哨淋巴结检测技术在喉癌N_0期病人治疗中的初步应用

Preliminary Application of Sentinel Lymph Nodes Detecting Technology in the Treatment of the N_0 Stage of Laryngocarcinoma

目的:采用前哨淋巴结检查技术对喉癌N0期病人颈淋巴结转移情况进行评估,以决定是否行颈清扫术。方法:采用蓝染料及同位素检测二者结合的方法,对32例N0期喉癌患者进行术中前哨淋巴结定位研究,并分别于术中、术后对前哨淋巴结进行常规病理和免疫组化病理检查。结果:32例中31例找到前哨淋巴结,病理阳性15例。结论:喉前哨淋巴结的定位和活检技术切实可行;前哨淋巴结检测能够准确预测颈淋巴结转移癌的状况。

Objective： The evaluation of neck lymph node metastasis in the patients with laryngecarcinoma NO stage, by using sentinel lymph nodes detecting technology, could determine whether the radical neck dissection, should be carried out or not. Methods： The positioning study on the sentinel nodes in the 32 patients with laryngecarcinoma NO stage in operation was undertaken by combination of blue - stain and radioimmunoassay. The conventional pathological immunohistochemistry stain of sentinel nodes was applied in operation and after operation. Results： The sentinel lymph nodes were found in 31 of 32 cases, among them, 15 cases were positive results in pathological examination. Conclusions ： The location and biopsy of sentinel lymph nodes are practical and feasible. Detecting sentinel lymph nodes could predict the condition of tumor metastasis.