摘要
3种肟类化合物(TMB4、LUH6和2-PAM-Cl)对辛硫磷抑制的鲫鱼、蟑螂和家蝇的乙酰胆碱酯酶(AChE)均具有重活化作用。初步比较研究了3种肟类化合物对中毒AChE的重活化能力,发现它们对被抑制的蟑螂和家蝇的AChE重活化能力差异不显著;但是对被抑制的鲫鱼的AChE来说,TMB4和L H6的重活化能力明显比2-PAM-Cl强。推测这3种肟类化合物对蟑螂、家蝇和鲫鱼的中毒AChE的活化能力的差异可能是由脊椎动物与无脊椎动物AChE本身的差异性造成的。
Three oximes, pralidoxime chloride （2-PAM-C1）, trimedoxime （TMB4 ） and obidoxime chlpride （LUH6） showed significant reactivations on poisoned acetylcholinesterase （ACHE） by phoxim. There were no significant differences between cockroach （Blattella germanica） and house fly （Musca domestica） in reactivations on poisoned AChE by the three oximes. However, the reactivations by TMB4 and LUH6 were significantly higher than that by 2-PAM-C1 in a fish （ Carassius auratus）. The differences of reactivations on poisoned AChE by the three oximes might resulted from the different characteristics of AChE between vertebrates and invertebrates.
出处
《华东昆虫学报》
2006年第4期301-304,共4页
Entomological Journal of East China
基金
科技部资助项目(5DFA30440)
福建省科技厅资助项目(05I002)
关键词
肟类化合物
乙酰胆碱酯酶
重活化
蟑螂
家蝇
鲫鱼
oximes
acetylcholinesterase
reactivation
Blattella germanic
Musca domestica
Carassius auratus
