糖调节受损患者血小板活化的研究

Study on the activation of platelet in patients with impaired glucose regulation.

目的探讨糖调节受损对血小板活化的影响,并对相关影响因素进行分析。方法将78例糖调节受损(IGR)患者分为空腹血糖受损组(IFG)、糖耐量受损组(IGT)、两者并存组(IFG+IGT),检测其血小板活化指标CD62P、CD63、CD41、CD61,并与糖化血红蛋白、血脂、尿微量白蛋白进行相关性分析。结果IFG组I、GT组I、FG+IGT组CD62P、CD63、CD41、CD61明显高于正常对照组(P<0.01)。血小板活化指标与糖化血红蛋白、尿微量白蛋白之间呈显著正相关,与胆固醇、甘油三脂、低密度脂蛋白无明显相关。结论糖调节受损患者已存在血小板活化增高,并与糖化血红蛋白、尿微量白蛋白呈正相关。

Objective To investigate the changes of platelet activation in patients with impaired glucose regulation （IGR） and relevant factors. Methods Seventy - eight IGR patients were divided into impaired fasting glucose （IFG） group, impaired glucose tolerance （IGT） and IFG ＋ IGT group according to OGTY results. The levels of platelet CD62p, CD63, CD41 and CD61 were determined by flow eytometry. The levels of HbA1 C, blood - lipid and urinary albumin excretion rate （UAER） were also measured. Restilts The levels of platelet CD62p, CD63, CD41 and CD61 were significantly higher in IFG group, IGT group and IFG ＋ IGT group as compared with those in control group （P 〈 0.05- 0.01 ） and the levels were positively correlated with the levels of HbAIC and UAER（HbA1C：r=0.47, r=0.43, r=0.35, r=0.39, P 〈0.05-0.01; UAER：r=0.53, r=0.51, r=0.39, r=0.41, P 〈 0.01）. Conclusion The levels platelet CD62p,CD63,CD41 and CD61 in patients with IGR are increased and they are positively correlated to the levels of HbA1C and UAER.