57例海南黎族2型糖尿病患者代谢特征分析

Analysis of metabolism characteristics of 57 Li nationality type 2 diabetes patients in Hainan Province.

目的总结、分析海南黎族2型糖尿病(T2DM)患者的临床代谢特点,提高其防治水平。方法109例无亲缘关系海南黎族人,其中正常对照组52例、T2DM组57例。所有研究对象均测量血压、身高、体重、腰臀比,并测定空腹血脂、空腹血糖、口服75g葡萄糖后30、120min血糖。结果与正常对照组比较,海南黎族T2DM组收缩压、舒张压明显升高;体重指数、腰臀比增加,存在明显内脏型肥胖;海南黎族T2DM组患者的空腹血糖、口服75g葡萄糖后30、120min血糖水平显著升高;甘油三酯、胆固醇、低密度脂蛋白也明显升高,但高密度脂蛋白无显著差异。结论海南黎族T2DM患者常合并存在代谢综合征,胰岛素抵抗可能是其发病基础。

Objective To analyze the metabolic characteristics in 57 Lizu patients with type 2 diabetes mellitus （T2DM）. Methods 57 Lizu adults with T2DM and 52 non- diabetic control subjects were studied. All subjects were measured height, weight, waist- hip ratio, blood pressure and blood lipid profiles. Fasting blood glucose, 30 minutes and 120 minutes blood glucose levels were measured in the Oral Glucose Tolerance Test （OGTT） in all subjects. Results Compared with those in the control group, systolic and diastolic blood pressures, BMI, waist - hip ratio were significantly increased in the T2DM patients. Fasting blood glucose, 30 minutes and 120 minutes blood glucose levels in the OGTT were significantly increased in the T2DM patients compared to the control subjects. Triglycerides, cholesterol and low - density lipoprotein also significantly increased in the T2DM group,, and there was no difference in high - density lipoprotein between the T2DM and control groups. Conclusion Most of Lizu patients with T2DM accompanied with metabolic syndrome, and insulin resistance may be the one mechanism of T2DM in Lizu patients.