皮质激素吸入对治疗哮喘急性发作的疗效观察

Observation on the effect of inhalation of glucocorticoid on acute onset of child asthma.

目的评价缓解期吸入皮质激素布地奈德气雾剂(普米克)对儿童哮喘急性发作时应用硫酸沙丁胺醇雾化溶液(万托林)和布地奈德混悬液(普米克令舒)二联雾化吸入治疗效果的影响。方法对38例哮喘急性发作儿童联合应用二联药物压力雾化吸入治疗,采用配对t检验观察治疗前后的疗效,应用秩和检验分析缓解期吸入皮质激素对急性发作时压力雾化吸入治疗效果的影响。结果缓解期规范吸入皮质激素组哮喘急性发作时,二联药物压力雾化吸入治疗效果优于不吸入和不规范吸入组(P<0.05);急性发作期二联药物压力雾化治疗效果满意。结论缓解期吸入皮质激素与发作期二联压力雾化吸入联合应用是治疗支气管哮喘理想、安全、有效的方法。

Objective To evaluate the effect of inhalation of salbutamol sulfate respirator solution in combination with budesonide suspension for inhalation on acute asthma children who were being treated with budesonide aerosol （glucocorticoid） in the relieved pefled. Methods The 38 acute asthma children were treated with salbutamol sulfate respirator solution in combination with budesonide suspension for inhalation and the therapeutic effect was assessed by rank sum test and compared with other control groups. Results The efticacy of inhalant of salbutamol sulfate respirator solution combined with budesonide suspension in treatment of asthma children at acute stage was stisfactory and superior to other groups without inhalation and without regular inhalation of the two drugs, showing significant difference （ P 〈 0.05）. Conclusion Inhalation of budesonide aerosol （glucocorticoid） and combined use of salbutamol sulfate respirator solution and budesonide suspension for inhalation are effective and safe therapies for treatment of asthma children at relieved period and acute stage.