湖南省人群戊型肝炎病毒感染状况初步分析

Analysis of infection status of HBE in population of Hunan Province.

目的了解湖南省一般人群中戊型肝炎病毒感染状况,为湖南省戊肝防制提供基本的依据。方法采用酶联免疫法检测一般人群血清标本抗-HEV IgM和IgG抗体。结果8个县(市、区)1,553名一般人群血清抗-HEV IgM和IgG抗体平均阳性率分别为0.32%、21.70%,8个县(市、区)一般人群抗-HEV IgG抗体阳性率差异较大,从最低为0至最高达70.73%;无论是全部8个县(市、区)还是4个抗-HEV IgG抗体阳性率高的县(市、区),一般人群中男、女性抗-HEV IgG抗体阳性率差异无显著性,且随着年龄的上升而上升。结论湖南省部分地区可能曾发生过戊肝爆发,但由于戊肝疫情监测的敏感性较低而未能及时发现。今后应加强对戊肝的监测和科学研究力度,掌握戊肝疫情变化动态和流行病学特征,降低戊肝发病率。

Objective To understand the infectious status of hepatitis E virus （HEV） in general population of Htman Province and provide a scientific basis for controlling the disease. Methods IgM and IgG Antibodies against HEV were detected with enzyme- linked immenosorbent assays （ELISA）. Results The average positive rates of IgM and IgG against HEV were 0.32 % and 21.70% in 1,553 persons in 8 counties （cities, districts）. The average positive rates of IgG varied greatly in 8 counties （cities, districts）, from 0 up to 70.73% ; There were no significant differences between male and female in IgG positive rates, and the IgG positive rates were increased along with the increase of age. Conclusion The outbreak of hepatitis E might have occurred in some areas without being detected due to lower sensitiveness of monitoring, detection and capability. Thus in - depth study and monitoring of hepatitis E be strengthened in the future in order to reduce incidence of hepatitis E.