母亲HBV不同感染状态母婴阻断效果评价

Evaluation on the results in monitoring of interruption of vertical transmission of HBV from mothers to their babies.

目的评价母亲HBV不同感染状态乙肝病毒母婴阻断效果,探讨经济、高效乙肝母婴阻断方案。方法利用血清流行病学方法进行调查和分析。结果济宁市使用的3种母婴阻断方案,母亲HBsAg单阳儿童母婴阻断率为92.45%,母亲HBsAg和HBeAg双阳儿童母婴阻断率为89.72%,儿童抗-HBs阳性率为85.21%。189名母亲单纯HBsAg阳性的儿童3种阻断方案HBV母婴阻断率(χ2=5.47,P>0.05)和抗-HBs阳性率(χ2=1.59,P>0.05),无显著性差异。183名母亲HBsAg和HBeAg双阳性的儿童,3种阻断方案HBV母婴阻断率(χ2=12.19,P<0.005)和抗-HBs阳性率(χ2=7.77,P<0.05),差异有显著性。结论济宁市目前母亲HBsAg阳性的儿童母婴阻断效果比较理想,今后要根据母亲HBV不同的感染状态,选择既经济又高效的母婴阻断方案。

Objeetive To evaluate the efficacy of interruption of perinatal transmission of HBV infection in the mothers in Jining City and explore economic and efficient scheme for interrupting perinatal transmission of HBV. Methods Serological survey was conducted and the results were analyzed. Results Based on the three kinds of program of interrupting perinatal transmission HBV in Jining City. The protective rate among the children born to HBsAg carrying mothers was 92.45 % and among the children loom to HBsAg and HBeAg carriying mothers was 89.72%. The positive rate of antiHBs was 85.21%. There no significant difference between the interruptive rate of perinatal transmission of HBV was observed （χ^2 = 5.47, P 〉 0.05） and the anti - HBs positive rate （χ^2 = 7.77, P 〈 0.025） among the 189 children loom to HBsAg carrier mothers. There was significant difference between the interruptive rate of HBV imerruption of perinatal transmission（χ^2 = 12.19, P 〈 0.005） and the anti - HBs positive rate （χ^2 = 7.77, P 〈 0.025） among the 183 children born to born to HBsAg and HBeAg carrier mothers. Conclusion The efficacy of interruption of perinatal transmission of HBV through HBsAg carriying mothers is much satisfactory in Jinning at present and effective and economic scheme for interruption of perinatal transmission of HBV be taken.