肝硬变门脉高压症病人肝组织中肾上腺素受体的变化

Abrenoceptors in the hepatic tissues in cirrhotic rats and cirrhotic patients with portal hypertension.

了解α１－肾上腺素受体在肝硬变门静脉高压症大鼠及病人肝组织中的变化，为肝硬变Ａ的治疗提供理论依据。方法应用３Ｈ－哌唑嗪对四氯化碳诱导的１８只大鼠肝硬变模型和８例乙型肝炎后肝硬变病人的肝组织进行了光学放射自显影研究。结果大鼠肝组织结构的α１肾上腺素受体密度（每１００００μｍ２银粒计数，正常／早期／中期／晚期）分别为：（１）肝细胞：９４６±１００／４３１±５４／５６７±９２／６９２±５５；肝动脉５８１±９０／２５０±８７／２７３±９２／２７３±８８；（２）门静脉：４７０±８３／２６０±７５／２５８±７７／２５３±８３；（３）肝静脉：３６２±９２／２２９±６４／２１８±８７。病人肝组织结构的α１－肾上腺素受体密度（每１００００μｍ２，正常／肝硬变）分别为：（１）肝细胞：１２５５±１５１／５８３±４８；（２）肝动脉：７０５±１８９／１８４±４７；门静脉４１０±８９／１５４±２１；（３）肝静脉：３３９±９５。结论肝硬变各期大鼠及病人肝组织结构α１－肾上腺素受体密度均明显低于各自正常组的相应组织结构（Ｐ＜０．

Objective To study the density of α 1 adrenoceptors on hepatic tissues of cirrhotic rats and cirrhotic patients with portal hypertension.Methods Alight autoradiography of α 1 adrenoceptors on hepatic tissues of Wistar rats in the processes of CCl 4 induced cirrhosis( n =18) and hepatitis virus B related cirrhotic patients( n =8)were studied.Rethods The density of α 1 adrenoceptors on hepatic tissues(per 10000μm 2)in rats(normal/cirrhotic early stage/cirrhotic middle stage/cirrhotic advanced stage)was 946±100/431±54/567±92/692±55 for hepatocytes,581±90/250±87/273±92/273±88 for intrahepatic artery walls,470±83/260±75/258±77/253±83 for intrahepatic portal walls,362±92/229±64/218±87/212±90 for hepatic venule walls and in patients(control human beings/cirrhotic patients) it was1255±151/583±48 for hepatocytes,705±189/184±47 for intrahepatic artery walls410±89/154±21 for intrahepatic portal walls339±95/……for hepatic venule walls.Conclusion The density of α 1 adrenoceptors on various hepatic structures in cirrhotic rats and cirrhotic patients are significantly lower than that in normal rats and control human beings( P <0.01).