摘要
目的探讨左旋卡尼丁(L—CN)对急性心肌梗死患者肌钙蛋白T(cTnT)和C-反应蛋白(CRP)含量的影响。方法2004年1~12月在沈阳医学院附属沈洲医院住院治疗的急性心肌梗死(AMI)患者25例,为试验组,给予L-CN4.0g/d,共用7d;另选AMI患者25例作为对照组。所有患者于用药前、用药第3天后,用药结束后检测cTnT和CRP。并于用药前和用药结束后行超声心动图检查及心肌灌注显像分析。结果用药前cTnT和CRP含量两组间差异无显著性意义(P〉0.05)。用药第3天后试验组cTnT和CRP较对照组下降但差异无显著性意义;用药结束后试验组cTnT和CRP较对照组显著减低(P〈0.05)。试验组在用药后左心室射血分数(LVEF)较对照组明显改善(P〈0.05),心肌缺损面积缩小(P〈0.05)。结论心肌梗死时给予L-CN治疗可降低血循环中cTnT和CRP含量,有利于心肌修复,缩小梗死面积。
Objective To investigate the effect of L-carnitine(L-CN) on cardiac troponin T(cTnT) and C-reactive protein(CRP) in patients with acute myocardial infarction(AMI). Methods A total of 25 patients suffering from AMI (trial group) were given L-CN 4.0 g/d,totally 7 days,and control group were given placebo. CTnT and CRP were analyzed at baseline ,given L-CN dieb tert and run-out L-CN in all patients. Echocardiography and ^99Tc-MIBI myocardial imaging were performed. Results There was no difference between two groups at baseline ( P 〉 0. 05) ; the levels of CTnT and CRP of trial group were lower than control group when given L-CN dieb tert( P 〉 0. 05 ), but significantly lower than control group when run-out L-CN ( P 〈 0. 05). LVEF of trial group was significantly higer than control group (/5 〈 0.05 ), and defect size decreased (P 〈 0. 05). Conclusion The levels of CTnT and CRP in patients with AMI depress if given L-CN.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第7期533-535,共3页
Chinese Journal of Practical Internal Medicine
关键词
心肌梗死
左旋卡尼丁
肌钙蛋白
C-反应蛋白
Myocardial infarction
L-carnitine
Cardiac troponin
C-reactive protein