药物制备异体动脉移植的超微结构研究

A STUDY OF ULTRASTRUCTURE OF ARTERY ALLOGRAFT PHARMACEUTICAL PERARED

目的：了解药物制备异体动脉移植前、后管壁组织构筑的演变及其与宿主的关系。方法：采用健康人尸动脉乙醚酒精法制备后１０、３０、６０、１２０天和手术移植后２月～２年的标本，分别行超微结构以观察。结果：（１）制备后管壁内皮细胞脱落，平滑肌细胞变性，细胞间纤维组织透明样变。（２）移植后内膜新内皮细胞生长；平滑肌细胞有可逆性变化，但整个中膜层向胶元纤维化发展；外膜形成纤维壁。结论：（１）制备后异体动脉抗原结构改变是其与宿主相容的解剖和生理学基础。（２）移植段内、外膜组织学变化有“免疫封闭”作用。（３）中膜层病理学改变是可逆性的，但已失去血管舒缩功能，仅具生物支架作用。

Objective:To find out the changes of tissue in the wall of artery, its pre and postpharmaceutical prepartion,its relationship with host.Methods:The ultrastructure of the arteries from health cadaver obseved respectively,on the 10th,30th,60th and 120th day after ethyl alcohol prepartion.Observing the samples grafted in 2 months to 2 years after operation. Results:(1)After prepartion, the endothelium of artery detached,smooth muscle cells degenerated,and hyalination of intercellular fibrous tissue,(2) After grafted,the new endothelium grown up in tunica intima,and reversible changes in smooth muscle cells,the whoie tunica media developed into collagenous fibrosis,the fibrous wall of external tunica formed. Conclusion:(1) The changes of antigen structure of prepared arteries made the compatibility with the host on the anatomic and physiological basis.(2) The histological changes of tunica intima and externa for grafting arteries had the effect of “immunological occlusion”.(3)The pathological changes of tunica media were reversible,without vasomotion and play a stent role only.