肝星状细胞与肝纤维化研究进展

The development about hepatic satellite cells and hepatic fibrosis

肝星状细胞(HSC)是肝脏的一种非实质细胞,HSC活化导致细胞外基质(ECM)的增加是肝纤维化形成并最终导致肝硬化、肝功能衰竭的主要原因。因此,加强对HSC激活与凋亡调控机制的研究,有助于我们对肝纤维化发生的本质的认识,从而能更有效地防治肝纤维化。

Hepatic satellite cell is one kind of non-parenchymal liver cells. Activation HSC is the main cell that lead to the accumulation of extracellular matrix, which is the main reason of hepatic fibrosis, cirrhosis, liver failure. Accordingly, future studies needed to be paid more attention to HSC regulating mechanism, which is beneficial to our knowledge about the essentiality of hepatic fibrosis, correspondingly, the treatment may work more effectively against hepatic fibrosis.