肝星状细胞凋亡调控因素的研究进展

Regulation of hepatic stellate cell apoptosis in liver fibrosis

诱导HSC凋亡成为阻止肝纤维化进程的途径之一。生长因子、死亡受体配体(TRAIL、FAS)、细胞外基质(胶原、整合素)、信号转导蛋白和转录因子(NF-κB、IKK、JNK)等多种因素参与调控HSC凋亡。

HSC apoptosis will promote the resolution of fibrosis. This review will consider the regulatory role played by growth factors, death receptor ligands （TRAIL, FAS）, extracellular matrix （integrins, collagen） and signal transduction proteins and transcription factors（NF-kB, IKK, JNK）.