二丙酸倍氯米松和干扰素吸入疗法治疗毛细支气管炎的临床研究

Effect of inhalation therapy of beclometasone and interferon for the treatment of bronchiolitis in children

目的 研究二丙酸倍氯米松和干扰素吸入疗法治疗毛细支气管炎（毛支）的临床疗效，评价其临床价值。方法 将83例毛支患儿随机分为两组，两组病例采用相同的综合治疗，治疗组（n=42）在综合治疗基础上，急性期行干扰素吸入治疗及缓解期行二丙酸倍氯米松长期吸入治疗，对治疗前后主要症状及体征的持续时间，平均住院天数进行比较。结果 急性期在治愈率、喘憋缓解、肺部哮鸣音及湿哕音消失时间及住院时间等方面，治疗组明显优于对照组（P〈0．01）。恢复期治疗组喘息率低于对照组。结论 急性期吸入干扰素有利于疾病的恢复，恢复期吸入二丙酸倍氯米松可减少喘息的发作。

Objective To explore effects of the beclomethasone-interferon inhalation therapy on bronchiolitis. Methods Eighty-three children with bronchiolitis were randomly divided into therapy group （n = 42） and control group （ n = 41）. The control group was given routine treatment, and additionally, the therapy group received inhalation therapy of beclometasone and interferon. The symptom/sign duration and average hospital stay time were compared between the two groups. Results During the acute stage, treatment group showed higher cure rate, more obvious asthma relief, less wheezing/wet tales and shorter hospital stay than control group （P 〈 0.01）. Asthma incidence at recovery stage was lower in therapy group as compared with control. Conclusion Interferon inhalation can improve the recovery of hronchiolitis at acute stage and be- clometasone inhalation can reduce the asthma attack during recovery stage.