纤维蛋白胶促进乳腺癌术后创面愈合的研究

A clinical observation of effect of fibrin glue on incisional wound healing of women underwent mastectomy due to breast cancer

目的探讨纤维蛋白胶在减少乳腺癌术后并发症中的作用。方法将45例乳腺癌患者随机分成实验组(24例)和对照组(21例)。实验组行乳腺癌改良根治术同时在手术创面喷涂纤维蛋白胶5mL,对照组仅行乳腺癌改良根治术。观察两组术后3天皮下引流量、拔管时间、皮下积液、皮瓣坏死和术后住院日的情况。结果实验组术后第1、2天引流量少于对照组(P<0.05),在术后第3天两组间存在明显差异(P<0.01)。术后拔管时间、皮下积液发生率和术后住院日少于对照组(P<0.05)。两组间皮瓣坏死发生率无明显差别(P>0.05)。结论应用纤维蛋白胶可有效地减少乳腺癌术后创面渗液,促进创面愈合。

Objective To observe effect of fibrin glue on incisional wound healing of women underwent mastectomy due to breast cancer. Methods 45 women with breast cancer were divided into two groups ： group A （ n = 24） and group B （ n = 21 ）. In group A, 5mL of fibrin glue were sprayed and smeared on the incisional wound in course of modified radical mastectomy. In group B, the patients received modified radical mastectomy only without use of fibrin glue in the operation. The total amount of subcutaneous drainage within first 3 days after operation, decannulation time, subcutaneous hydrops, necrosis of the skin flap, and average hospital stay in the two groups were observed. Results The subcutaneous drainage amount at either the first day or the second day after operation was significantly less in group A as compared with group B （ P 〈 O. 05 ）, and at the third day after operation, in subcutaneous drainage amount there was a significant difference between the two groups（P 〈 O. O1 ）. The duration of drainage, subcutaneous hydrops rate and postoperative hospital stay in the group A were shorter and less than those in the group B. In incidence of necrosis of skin flaps, there was no significant difference between the two groups（P 〉0.05）. Conclusion Fibrin glue could effectively decrease the incisional wound exudates and promote healing of the incisional wound.