生长激素对卵巢功能的影响

Effects of growth hormone on ovary function

生长激素通过直接与卵巢上生长激素受体结合,或者借助胰岛素样生长因子的作用影响卵巢功能。基础研究表明生长素可以影响窦前卵泡及窦卵泡生长,抑制卵泡闭锁,促进卵泡成熟,增加排卵数,并且可能影响性激素产生。基于上述原因,不少学者探讨了生长激素在人类辅助促排卵治疗中的应用价值,期待生长素能够改善促排卵治疗效果,但是目前的结果有争议。改进生长激素使用方案可能改善疗效。

By directly binding to receptors on the ovary or through insulin like growth factor （IGF）, growth hormone （GH） acts on the ovary. Basic medical researches demonstrated that GH can stimulate development and maturation of the follicles, increase the number of ovulation, even has some effects on synthesis of sexual hormone. Thereby, some scholars explored practical values of GH in human adjuvant ovulation stimulation, but the research results wero controversial. Future studies should focus on improving regimen of GH in adjuvant ovulation stimulation.