年龄对^(85)Sr在大鼠体内滞留、分布及剂量的影响

AGE INFLUENCE ON RETENTION,DISTRIBUTION AND INTERNAL DOSES OF ^(85)Sr IN RAT

^(85)Sr注入静脉后,大鼠全身Sr的滞留可拟合成二项指数方程,方程参数在幼年组与成年、老年组间有显著差异(P<0.01),而成年与老年组之间差异不明显,慢库室的生物半排期Tb_2从幼年至老年组依次减小。骨滞留方程中,幼年组的生物半排期明显小于成年组和老年组。估算的全身及红骨髓剂量,幼年组是成年组的4.2倍,是老年组的6.2和5.9倍。剂量累积速度以幼年组最快,成年和老年组大致相等。

After I. V ^(85)Sr, the whole body ^(85)Sr-retentions in rats were fit totwo compartment exponential equations. The equation parameters showed a sigificantlydifference between the young group and both the adult and old groups (p<0 .01). butthere is no significant difference seen between the latter two groups. The biologicalhalf life(Tb_2) for ^(85)Sr in the slow compartment decreased in regular order from theyoung to the old groups. 1n the bone ^(85)Sr-retention equations Tb_2 of the slow compa-rtment for ^(85)Sr in the young group was sigificantly lower than the adult and oldgroups. The doses of the whole body and red-marrow for young rats were 4.2 timesas much as those of adult rats, and 6.2 and 5.9 times as much as those old rats. Thedose-cumulative speeds was most quick in the young groups and similar in the adultand the old.