肠道菌群失调与脂肪肝患者血脂和丙氨酸氨基转移酶的变化研究

Study on the change of TG,CHOT,LDL ALT in serum of fatty liver suffering with intestinal dysbacteriosis

目的探讨脂肪肝患者体内甘油三酯(TG)、血清总胆固醇(CHOL)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、丙氨酸氨基转移酶(ALT)与肠道菌群失调的关系。方法单一他汀类降脂药物治疗高脂血症,测定肠道菌群失调与肠道菌群正常的脂肪肝患者血清TG、CHOL、HDL、LDL、ALT。结果无菌群失调组,ALT升高者占11%,治疗缓解率为87%,而菌群失调组ALT升高占37%,治疗缓解率为67%,两者差异有显著性。结论正常肠道的菌群对血脂代谢以及高脂血症的治疗起着重要作用。

Objective To discuss the relation of TG,CHOL,HDL,LDL,ALT and intestinal dysbacteriosis. Method The TG, CHOL, HDL, LDL,ALT were determented. Before and after therapy with drugs. Results In the non-intestinal dysbacteriosis group： ALT increased 11% ,87% relieved after therapy. Therefore in the intestinal dysbacteriosis group： ALT increased 37% ,67% sufferers relieved,there was distinctive difference between the two groups. Conclusion The normal flora in intestinal is very important to fat metabolism and drugs therapy.