摘要
目的研究胃癌相关抗原MG7Ag在胃癌中的表达及其意义。方法采用流式细胞仪检测143例胃癌组织中MG7Ag的表达,同时随机选取30例慢性浅表性胃炎,30例慢性萎缩性胃炎,作为对照研究。结果MG7Ag阳性表达在胃癌、慢性浅表性胃炎、慢性萎缩性胃炎中分别为91.3%、14.9%、30.0%。胃癌MG7Ag阳性表达与胃癌有无淋巴结转移无相关性(P>0.05),胃癌MG7Ag阳性表达与胃癌分化程度亦无相关性(P>0.05)。结论从慢性浅表性胃炎→慢性萎缩性胃炎→胃癌,MG7Ag阳性表达率显著递增,与胃癌的浸润转移无明显相关性,MG7Ag有望成为临床上诊断胃癌可靠的肿瘤标记物。
Objective To explore the expression and significance of tumor - associated antigen MG7Ag in gastric carcinoma. Methods The expression of MG7Ag in 143 patients with gastric carcinoma was determined by flow cytometry （FCM）, meanwhile, 30 patients with chronic superficial gastritis and 30 patients with chronic atrophic gastritis were served as control. Results The findings showed that MG7Ag positive in 130/143 cases, in 5/30 with chronic superficial gastritis and in 9/30 with chronic atrophic gastritis. In gastric carcinoma, the expression pattern of MG7Ag has no relation of tumor coil differentiation with metastasis of lymph nodes. Conclusion From chronic superficial gastritis and chronic atrophic gastritis to gastric carcinoma expression of MG7Ag showed an ascending tendency; MG7Ag can be used as a reliable marker in gastric cancer. MG7Ag is not associated with infdtration and metastasis of gastric cancer.
出处
《宁夏医学杂志》
CAS
2007年第4期313-314,共2页
Ningxia Medical Journal
