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JC病毒研究进展及其在人类起源研究中的应用

Progresses of Research on JC Virus and Applications in Studies on Origin of Mankind
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摘要 综述了JC病毒的遗传特性、传播途径及相关疾病。JC病毒是人类多瘤病毒的一种,在人群中广泛存在。JC病毒感染发生在人的童年时期,没有明显的症状,对绝大多数人没有危害,但对于免疫力缺陷和长期服用免疫抑制药物的患者,能够引起致命的进行性多灶性白质脑病(Procreative Multifocal Leukoence Phalopathy,PML)。由于JC病毒属无症状感染,其具体感染途径至今不清楚。JC病毒具有家庭内部传播的特点,从父母传给子女,属事实上的垂直传播。因此,可以通过研究JC病毒的基因分型来研究人类的起源和迁移。 The human polyomavirus JC virus, is ubiquitous in the human population and harmless for majority of individuals, infecting children asymptomatically. The JC virus is the etiologic agent of the fatal demyelinating disease Progressive Multifocal Leukoence phalopathy （PML） in immunocompromised individuals. However, there is no information available regarding the route of transmission, mainly because no obvious symptom is correlated with JC virus infection. The transmission of JC virus is considered virtually vertically from parents to children within the family. Thus the genotype identified as nucleartide polymophis of JC virus can be used as markers of ancient groups, which offers a novel means of tracing human migrations.
作者 黄耀江 张桂根 沈光涛 冯金朝
机构地区 中央民族大学生命与环境科学学院
出处 《科技导报》 CAS CSCD 2007年第8期44-46,共3页 Science & Technology Review
基金 面向21世纪教育振兴行动计划985工程项目(CUN985-3-3) 北京市教委知识产权实施项目
关键词 JC病毒 基因型 人类起源 JC virus genotype origin of mankind
分类号 Q98 [生物学—人类学] Q939.4 [生物学—微生物学]
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参考文献17

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二级参考文献19

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2007年 第8期

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