摘要
为探讨肿瘤转移抑制基因nm23与涎腺腺样囊性癌(adenoidcysticcarcinoma,ACC)的关系,应用LSAB免疫组化染色方法,研究nm23表达产物二磷酸核苷激酶(nucleosidediphosphateki-nase,NDPK)在ACC中的表达。结果:NDPK/nm23在ACC中有较高表达,阳性率为64.0%(16/25);其中,有肺转移者阳性率为12.5%(1/8),无肺转移者阳性率为88.2%(15/17),差异有极显著性(P<0.01);NDPK表达与临床分期有关,分期越高,阳性率越低,差异有显著性(P<0.05),与病理分型差异无显著性(P>0.05)。结论:nm23基因在人ACC肺转移过程中起到抑制转移的作用,可作为临床颈侧ACC患者转移和预后的指标。
The nm23 gene products, nucleoside diphosphate kinase (NDPK), expression in salivary adenoid cystic carcinoma (ACC) was evaluted by using LSAB immunohistochemical method. Of 25 cases tested, 16 (64.0%) showed positive staining, in which, higher incidence of positive staining was found in ACC without lung metastasis (88.2%, 15/17) than in that with lung metastasis (12.5%, 1/8; P <0.01). Expression of NDPK/nm23 was correlated with the P TNM pattern ( P <0 05), otherwise it was not correlated with pathologic types ( P >0 05). The result suggest that the nm23/NDPK may play a role in suppressing the metastatic potential in ACC.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
1997年第1期4-6,共3页
Chinese Journal of Stomatology
基金
国家自然科学基金
关键词
涎腺肿瘤
腺样囊性癌
肺转移
NM23基因
Carcinoma, adenoid cystic Gene, suppressor, tumor Immunohistochemistry nm23 gene