nm23基因在涎腺腺样囊性癌中的表达及其与肺转移的关系

nm23 expression and its correlation with lung metastasis in human salivary adenoid cystic carcinoma

为探讨肿瘤转移抑制基因ｎｍ２３与涎腺腺样囊性癌（ａｄｅｎｏｉｄｃｙｓｔｉｃｃａｒｃｉｎｏｍａ，ＡＣＣ）的关系，应用ＬＳＡＢ免疫组化染色方法，研究ｎｍ２３表达产物二磷酸核苷激酶（ｎｕｃｌｅｏｓｉｄｅｄｉｐｈｏｓｐｈａｔｅｋｉ－ｎａｓｅ，ＮＤＰＫ）在ＡＣＣ中的表达。结果：ＮＤＰＫ／ｎｍ２３在ＡＣＣ中有较高表达，阳性率为６４．０％（１６／２５）；其中，有肺转移者阳性率为１２．５％（１／８），无肺转移者阳性率为８８．２％（１５／１７），差异有极显著性（Ｐ＜０．０１）；ＮＤＰＫ表达与临床分期有关，分期越高，阳性率越低，差异有显著性（Ｐ＜０．０５），与病理分型差异无显著性（Ｐ＞０．０５）。结论：ｎｍ２３基因在人ＡＣＣ肺转移过程中起到抑制转移的作用，可作为临床颈侧ＡＣＣ患者转移和预后的指标。

The nm23 gene products, nucleoside diphosphate kinase (NDPK), expression in salivary adenoid cystic carcinoma (ACC) was evaluted by using LSAB immunohistochemical method. Of 25 cases tested, 16 (64.0%) showed positive staining, in which, higher incidence of positive staining was found in ACC without lung metastasis (88.2%, 15/17) than in that with lung metastasis (12.5%, 1/8; P <0.01). Expression of NDPK/nm23 was correlated with the P TNM pattern ( P <0 05), otherwise it was not correlated with pathologic types ( P >0 05). The result suggest that the nm23/NDPK may play a role in suppressing the metastatic potential in ACC.