致密型珊瑚骨修复皮质骨缺损的实验研究

Experimental study on bone formation in a denser coral used for repairing cortical defects in dogs

为了寻找新的骨代用品，作者采用产自海南岛的角蜂巢珊瑚（ｆａｖｉｔｅｓ）作原料，制成珊瑚人工骨。理化测定显示Ｆａｖｉｔｅｓ的化学成分与滨珊瑚（ｐｏｒｉｔｅｓ）相同，但孔隙结构不同，孔率较少，质地较致密，强度较高。植入狗下颌骨和股骨皮质缺损内，具有良好的生物相容性和骨亲和性，６～８个月后植入物逐渐降解而被新骨完全替代，皮质骨缺损得到完全修复并保持其强度。结果表明该人工骨可能成为颌骨节段性缺损的修复材料之一。

The present study was designed to investigate a coral skeleton,Favites,which was originated from the reef builders in Hainan island,as a bone substitute.The coral Favites,like porites,is composed of anagonite(CaCO3),but contains less volume of porosity,higher strength and denser construction than Porites.After implanted into cortical bone defects in mandibles and femurs of dogs, skeleton fragment of coral Favites demonstrated good biocompatibility and biodegradability.A resorption of the implant and a simultaneous apposition of new bone was observed.Coral Favites was totally replaced by newly formed bone after a period of time from 6～8 months.Compared to Porites,Favites has a lower rate of resorption and therefore the defects of host bone are repaired completely without any lost of bone volume.The results showed that coral Favites may be used as a bone substitute for the segmental defects of mandibles.