白细胞介素1加速兔牙齿移动的实验研究

Effects of IL 1 on experimental tooth movement in rabbits

为探讨白细胞介素１（ｉｎｔｅｒｌｅｕｋｉｎ１，ＩＬ－１）对正畸牙齿移动的影响及对牙槽骨的作用，选用１２只大耳白兔分为２组，一组为对照组，另一组注射ＩＬ－１。对２组动物进行牙齿移动距离的测量、破骨细胞计数和组织学观察。结果表明：ＩＬ－１能够加速正畸牙齿移动，可以增加牙周组织中的破骨细胞，并能加速牙槽骨的改建。

The purpose of this study was to search the effects of IL 1 on the orthodontic tooth movement and alveolar bone by animal experiment. The distance of tooth movement was measured and histologic changes were observed. 12 rabbits were divided into two groups.IL 1 was injected in the gingiva around the moving tooth of the experimental group.The rate of tooth movement and the number of osteoclasts of the two groups were compared.The results suggested that IL 1 can promote the tooth movement and increase the number of osteoclasts and can also promote bone remodelling.