糖尿病大鼠牙槽骨骨密度的变化

The alveolar bone density in rats with experimental diabetes

为了评价糖尿病大鼠牙槽骨代谢情况，采用放射免疫分析检测其血清骨钙素浓度，以双能量Ｘ线骨密度测量仪测量牙槽骨骨密度并结合组织学观察。结果表明，糖尿病大鼠血清骨钙素浓度升高，股骨与上、下牙槽骨骨密度降低，牙槽骨骨小梁变细变疏、骨吸收活跃，新骨形成减少。本研究结果提示，糖尿病大鼠牙槽骨骨吸收活跃，骨形成缓慢，有骨质疏松倾向。

The alveolar bone turnover in rat with experimental diabetes was investigated.The serum osteocalcin concentration in diabetic rat was shown to increase as determined by radioimmunoassay;while alveolar and femur bone density decrease as determined by Dual Energy X ray Bone Densitometer;histological examination showed that bone resorption was increased and bone formation decreased in the alveolar bone in diabetic rat. It is suggested that the alveolar bone in rats with diabetes mellitus have a tendency to develop osteoporosis.