血尿酸和胆红素水平变化与冠心病的关系研究

Correlation between serum uricacid,bilirubin and coronary artery disease

目的探讨血尿酸和胆红素与冠心病(CHD)的关系。方法回顾性分析84例行选择性冠状动脉造影的病人,分为冠心病组(狭窄≥50%)与对照组(冠状动脉造影阴性),分析各组血清尿酸、胆红素水平的差异及与冠状动脉严重程度的相关性。结果冠心病组血尿酸水平明显高于对照组(P<0.05),而且血尿酸升高与冠状动脉狭窄程度显正相关,总胆红素水平明显低于对照组(P<0.05),且与冠状动脉狭窄程度显负相关。结论血尿酸升高,血清总胆红素水平降低与冠心病密切相关,可能在冠心病的发生发展中起着一定的作用。

Aim To explore the relationship between the level of serum uric acid （SUA） ,bilirubin and coronary heart disease. Methods Eighty-four patients were selected for coronary angiography （CAG） and analyzed retrospectively. They were divided into two groups by their results of coronary angiography： 1. CHD （ ≥ 50% diameter narrowing） 2. Normal （ coronary angiography negative subjects）. The difference in level of SUA and bilirubin were compared in two groups, and correlation of them with coronary artery score and number of tenosed branch were analyzed. Results The level of SUA and Total Bilirubin （TBIL） were significantly different between the CHD group and the control group（ P 〈 0.05 ）. The level of SUA positively related with the severity of CHD. The level of TBIL negatively related with it. Conclusion The increase in SUA, and decrease of TBIL are closely related with the severity of CHD. They are likely to play a certain role in the genesis and progress of CHD.