乳杆菌阴道泡腾片与甲硝唑治疗细菌性阴道炎的疗效比较

Therapeutic effect comparison between Lactobacilli and Metronidazole in bacterial vaginitis

目的观察乳杆菌阴道泡腾片治疗细菌性阴道炎的疗效。方法采用双盲、随机对照的方法,在4家医院的妇产科门诊将232例患者分成试验组(n=116)和对照组(n=116)。试验组用药为乳杆菌阴道泡腾片、对照组用药为甲硝唑阴道泡腾片,阴道放置,每晚1片,疗程7 d。治疗前后分别进行临床症状评分、测阴道分泌物pH、做线索细胞和胺试验检查,进行总有效率评定。结果经2种药物治疗后所有患者临床症状均明显减轻,治疗前后自身比较差异有显著性(P<0.01);80%以上的患者呈现线索细胞转(-)、胺试验转(-),超过一半的患者阴道分泌物pH低于4.5;临床治疗总有效率分别为74.78%和83.33%。2种药物组间比较治疗效果差异无显著性(P>0.05)。结论阴道补充乳杆菌与使用甲硝唑治疗产生了相似的效果,有可能成为新的治疗细菌性阴道炎的方法。

Objective To observe the therapeutic effect of Lactobacillus Lactis Vaginal Effervescent Tablets （ LB） in bacterial vaginitis. Methods We did a double-blind, randomized controlled trial in 4 perinatal centers. 232 patients were vaginal treated with Lactobacilli （ LB group, n = 116 ） or Metronidazole （ Control group, n = 116 ） once a day for 7 days. Assessment of clinical symptoms, measurement of pH , clew cells and ammonia test of vaginal swab specimen were made at the beginning and the end of the trial. Results Most symptoms were extenuation after the treatment of the 2 drugs. There were significant differences between pretherapy and post-treatment in themselves （ P 〈 0.01 ）. And the pH values of vaginal specimen were less than 4.5 in about 50% samples. More than 80% samples were negative in the measurement of clew cells and ammonia test. The total efficacy rates were 74.78% and 83.33%. There were no significant differences between the two groups （ P 〉 0.05 ）. Conclusion Intra-vaginal administration of LB had same effects as Metronidazole and it may be a new method in the treatment of bacterial vaginits.