云南白药对非血运重建急性Q波心肌梗死患者伴有室壁瘤的影响

The Influence of Yunnan White Drug-powder On the Patients with Non-blood Circulation Reconstruction Acute Q-wave Myocardial Infarction and Ventricular Aneurysm

观察云南白药对急性心肌梗死并伴发室壁瘤患者的影响。方法:确定非血运重建的急性Q波心肌梗死伴有室壁瘤的患者30例,随机分2组。一组常规治疗加服云南白药胶囊(治疗组),另一组常规治疗(对照组)。试验观察前后记录患者体征、心率、血压、心电图、二维彩色多普勒检查和检测患者血清炎症因子水平。结果:服用云南白药患者有减少室壁瘤数量发生的趋势,经统计学处理无显著差异,两组死亡率统计无显著差异。云南白药可降低患者血清白介素—6(IL-6)、白介素—8(IL-8)含量和高敏C-反应蛋白(hs-CRP)水平,和治疗前比较差异显著(P<0.05和P<0.01)。结论:云南白药具有减少非血运重建条件下急性Q波心肌梗死伴有室壁瘤数目的趋向,抑制患者机体内的炎症因子水平,其机理有待进一步深入研究。

Objective： To study the effect of the influence of Yunnan White Drug-powder on the patients with non-blood circulation reconstruction acute Q-wave myocardial infarction and ventricular aneurysm. Methods： To select 42 patients who suffered from pure Q-wave AMI from 1997 -2004 in 3 hospitals, Before and after the treatment, we ask complains, measure heart rate, blood pressure, blood routine, urine routine, stool routine, ECG, renal and liver function, blood biochemical markers, two-dimensional Ultrasonic Cardiogram. （ one kind of machine used by the same skilled person. ）. Each member in the observed group takes Yunnan White Drug-powder 0. 25 q. i. d from the beginning till 60 days after AMI （ to take the drug with warm water, take no broad bean during the trial and there are more than 30 minutes interval separating other medicines） and the members in the control group did not take Yunnan White Drug-powder and placebo. Results： Among the 30 patients, there are 2 patients passed away in the control group （ include ： I can not take ACE inhibitor） and 3 passed away in the observed group （include： I cna not take ACE inhibitor）. Except the 5 patients, all the others finish the trial. Discussion： Yunnan White Drug-powder （OTC drug） has good effect and security in dealing with wound, which were enough data to support in pharmacopoeia in China. In modern research, the drug may reduce the level of hormone of adrenal, also has the ability of anti-inflammation. That may be some of the reasons why it maybe has functions in preventing ventricular aneurysm.