摘要
三氯蔗糖是性能最为优良的高甜度甜味剂之一。蔗糖-6-乙酸酯的选择性氯化是合成三氯蔗糖的关键步骤。蔗糖酯化合成的蔗糖-6-乙酸酯,不经纯化,经适当处理直接进入氯化阶段,用氯化亚砜与DMF预先生成的Vilsmeier试剂对其进行氯化,该方法具有收率高、操作简便及后处理容易等特点。优化的工艺条件为反应温度115℃,SOCl2与蔗糖-6-乙酸酯的摩尔比10∶1,DMF(mL)与蔗糖-6-乙酸酯(g)之比12∶1及反应时间3h。对中间产物三氯蔗糖-6-乙酸酯,经熔点测定、IR及1H-NMR确认了结构。
Sucralose is a kind of high intensity sweetener with significant characteristics. Selecting chlorination of hydroxyl group in sucrose 6-acetate is a key in the process of making sucralose. Sucrose-6-acetate, prepared by using triethyl orthoacetate without crystallization, could be chlorinated by Vilsmeier reagent which was subjected thionyl chloride to DMF. This method had many advantages： high yield, easy operation and easy process. Optimum condition was： reaction temperature 115℃, the mole ratio of SOCl2 and sucrose 6- acetate 10：1, the ratio of DMF（mL） and sucrose 6-acetate（g）12：1, reaction time 3h. The structure of the last compound was confirmed by using melting point mensuration, IR and^1H-NMR.
出处
《食品科技》
CAS
北大核心
2007年第3期158-161,共4页
Food Science and Technology
