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原发性高血压的基因机制-RAAS系统基因多态性 被引量:3

Genetic basis of essential hypertension-Gene polymorphisms of renin-angiontensin-aldosterone system
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摘要 原发性高血压(EH)是遗传和环境因素相互作用所致的多因素疾病,对其基因机制的研究有助于从分子水平探讨EH的发病机制.近年来对于EH候选基因多态性的研究逐渐增多,本文即对肾素-血管紧张素-醛固酮系统(RAAS)基因多态性与EH之间的关系的研究进展作一综述. Essential hypertension (EH) is a complex disorder resulting from interaction of genetic and environmental factors. Identify its genetic basis is important in understanding the molecular mechanisms of EH. Recently, more and more candidate genes have been found. This review is to discuss the highlight current studies of the association between the gene polymorphisms of renin-angiontensin-aldosterone system and EH.
作者 韩姗 丛洪良
出处 《中国心血管杂志》 2007年第2期138-140,共3页 Chinese Journal of Cardiovascular Medicine
关键词 原发性高血压 肾素-血管紧张素-醛固酮系统 基因多态性 Essential hypertension Renin-angiontensin-aldosterone system Gene polymorphism
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  • 1Halushka MK,Fan JB,Bentley K,et al.Patterns of single-nucleotide polymorphismsin candidate genes for blood-pressure homeostasis[J].Nat Genet,1999,22:239-247.
  • 2Linda J,Mullins,Matthew A,et al.Hypertension,kidney,and transgenics:A fresh perspective[J].Physiol Rev,2006,86:709-746.
  • 3唐敏,戴勇,涂植光.原发性高血压基因机制研究进展[J].国际检验医学杂志,2006,27(1):61-64. 被引量:21
  • 4Matthew E,Dickson,Curt D,et al.Genetic basis of hypertension revisiting angiotensinogen.Hypertension[J],2006,48:14-20.
  • 5刘艳,金玮,姜正文,张奎星,盛海辉,金璘,沈亚云,黄薇,于金德.血管紧张素原基因的六种单核苷酸多态与原发性高血压的相关性[J].中华医学遗传学杂志,2004,21(2):116-119. 被引量:16
  • 6Procopciuc LM,Pop D,Zdrenghea D,et al.Genetic analysis of angiotensinogen gene polymorphisms (M235T and T174M) in Romanian patients with essential arterial hypertension[J].Rom J Intern Med,2005,43:61-71.
  • 7Robinson M,Williams SM.Role of two angiotensinogen polymorphisms in blood pressure variation[J].J Hum Hypertens,2004,18:865-869.
  • 8Jain S,Li Y,Patil S,et al.A single-nucleotide polymorphism in human angiotensinogen gene is associated with essential hypertension and affects glucocorticoid induced promoter activity[J].J Mol Med,2005,83:121-131.
  • 9Gunes HV,Ata N,Degirmenci I,et al.Frequency of angiotensin-converting enzyme gene polymorphism in Turkish hypertensive patients[J].Int J Clin Pract,2004,58:838-843.
  • 10Espinel E,Tovar JL,Borrellas J,et al.Angiotensinconverting enzyme i/d polymorphism in patients with malignant hypertension[J].J Clin Hypertens,2005,7:11-15.

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