急性冠脉综合征血清C-反应蛋白的变化

The levels of C-reactive protein in patients with acute coronary syndrome

目的观察C-反应蛋白在冠心病急性冠脉综合征（ACS）时的变化，以了解ACS与炎症之间的关系。方法测定ACS组45例急性心肌梗塞（AMI）、56例不稳定型心绞痛（UA）病人血清CRP含量，与50例稳定型心绞痛（SA）对照。结果ACS中CRP增高，AMI升高最为明显，AMI与UA、AMI与SA、UA与SA之间比较，结果均有显著差异（P〈0．01）。病人近期心脏主要事件的发生比AMI组与UA组与SA比较，均有显著差异（P〈0．01）。结论血清CRP（C-反应蛋白）是预测ACS心肌损伤程度以及近期预后的有效指标。

Objective To study the levels of C-reactive protein （CRP） in acute coronary syndrome （ACS） and to explore the correlation between ACS and inflammation. Methods Ultrasensitive immunoassay was used to measure CRP levels in 45 patients with acute myocardial infarction （AMI） and 56 patients with unstable angina pectoris（UA）, and compared to 50 patients with stable angina pectoris （SA）. Results CRP levels were higher in ACS including AMI and UA compared with SA respectively （P〈0.01） （especially higher in AMI）. Recent acute coronary events are higher in AMI and UA than SA respectively （P〈0.01）. Conclusion These results suggest that CRP is a useful marker in prognosis of myocardial injuries of ACS.