SARS病人治愈后随访13个月细胞因子指标的变化

Changes of cytokines level in SARS patients during 13-month follow-up after recuperation

目的探讨严重急性呼吸综合征（SARS）病人远期细胞因子动态变化及规律。方法采用酶联免疫吸附法（ELISA）检测SARS病人痊愈后mo4、mo10及mo13的血清中IL—1β、TNFα,、TGFβ水平。结果111例病人中，IL—1β升高比率在随访的mo4、mo10、mo13分别为0％、48．6％、18．9％；TNFα升高比率在随访的mo4、mo10、mo13分别为26．1％、0．8％、3．6％；TG邱升高比率在随访的mo4、mo10、mo13分别为93．7％、97．3％、100％。结论随访SARS病人康复后血清的IL—1β、TNFα,和TGF-β水平呈波动状态，炎性细胞因子呈递降趋势，而抗炎性因子呈递升趋势，这种趋势发展是一个长期的过程。

Objective To investigate the changes and rules of cytokines among SARS （Severe acute respiratory syndrome） patients during follow-up. Methods All enrolled patients＇ IL-1β, TNFα and TGFβ were examined by using enzyme-linked immunoassay test in the fourth, tenth and thirteenth month after recuperation. Results In those 111 subjects, the rate of elevated IL-1β in the fourth, tenth and thirteenth month visit were 0%, 48.6%, 18.9% respectively; the rate of elevated TNFα in the fourth, tenth and thirteenth month visit were 26.1%, 0.8%, 3.6% respectively; whereas the rate of elevated TGFβ in the fourth, tenth and thirteenth month visit were 93.7%, 97.3%, 100% respectively. Conclusions During the follow-up period, the serum IL-1β, TNFα and TGFβ level of SARS patients are fluctuated. The inflammation cytokines have a tendency to decrease while anti-inflammation cytokines show a tendency to increase. The trend of cytokines change is lasting in a very long period.