口服胺碘酮叠加静脉滴注转复慢性心房颤动53例临床分析

Clinical analysis on 53 cases of chronic atrial fibrillation reverted with amiodarone orally and intravenously

目的观察口服胺碘酮叠加静脉滴注的方法转复慢性心房颤动的成功率及毒副作用。方法对53例慢性心房颤动患者给予静脉滴注胺碘酮3d左右,每日静脉总量1200～1800mg。静脉用药的第一天开始口服胺碘酮0.8～1.2g,分3次。5d后改为0.2g,每日3次。累计总量达8～12g后,每日一次口服0.2g维持。结果心房颤动转复成功率为79.2%,转复所需胺碘酮的平均累计剂量(9.41±1.24)g,未见严重毒副作用。结论口服胺碘酮叠加静脉滴注转复慢性心房颤动成功率高,毒副作用小,使用安全。

Objective To analyze the efficacy and side effect of amiodarone taking orally and intravenously on chronic atrial fibrillation treatment. Methods Fifty-three patients of chronic atrial fibrillation entered the study. First, they were treated with amiodarone orally（0. 8 - 1.2 g/d）and intravenously （1.2 - 1.8 g/d）for three days. Second, they were taken orally in the same dose and stopped intravenous drip for two days. Third, they were given orally at 0. 6 g/d from the sixth day. Fourth, they were kept on giving amiodarone orally at 0. 2 g/ d when the dose amounted to 8 - 12 g. Results Fourty two patients returned to sinus rhythm（79. 2% ） ,and the average reverting dose was （9.41 ± 1.24） g. No severe side effect was observed. Conclusion Taking amiodarone orally and intravenously is effective and safe on the treatment of chronic atrial fibrillation.