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单克隆抗体药物在乳腺癌治疗中的应用及进展

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摘要 目的介绍近年来单抗药物在乳腺癌治疗中的应用及进展。方法检索国内外相关资料,并进行汇总、分析和综述。结果乳腺癌的治疗中单抗药物的应用有单克隆抗体导向药物、免疫偶联物、双特异性单克隆抗体药物等多种类型。结论单抗药物是乳腺癌治疗史上一个重要里程碑,有着广泛的前景。
作者 李咪咪 陈莉
出处 《海峡药学》 2007年第4期1-3,共3页 Strait Pharmaceutical Journal
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参考文献16

  • 1惠锐.乳腺癌的现代疗法[J].中国全科医学,2004,7(8):586-587. 被引量:12
  • 2张天民.单克隆抗体药物的研究进展[J].医药导报,2005,24(6):494-498. 被引量:9
  • 3张敏,朱虹光.抗HER2单克隆抗体研究新进展[J].国外医学(生理病理科学与临床分册),2003,23(3):257-259. 被引量:5
  • 4Manfred Katlfnlarln,Lothar Kanz.Immuntherapie der Mammakarzinome mit Herceptin Neue Entwicklungen bei der Therapie des metastasierten Mammakarzinoms[J].Dentsche Medizin,2001,18 (3):
  • 5Stever SH.For the herceptin muItinatinonaI in vestigator study group.Overview of the trastuzumab(Herceptin)in HER-2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer[J].Semin Oncol,1999,26:12~ 71.
  • 6Bustein HJ,Kuter I,Richdrdson PG,et al.Herceptin and vi-noelbine for HEl 2 positive metastatic breast cancer:a phase (I) study[J].Proc Am Soc Clin Oncol,2000,36:387~92.
  • 7Pegram MD,Slamon DJ,Dennis JS,et al.Combination therapy with trastuz umab (herceptin) and cisplatin for chemoresist intantmetastatic breast cancer; evidence for receptor-enhanced chemo-sensitive[J].Semin Oncol,1999,26:82 ~ 9.
  • 8Makuwer D,Sparano JA,Wadler S,et al.A pilot study of edrecolomab and capcitabine in patients with advanced or metastatic adenocarcinoma[J].Cancer Investig,2003,21 (2):177~184.
  • 9Albanell J,Codony,J,Rovira A,et al.Mechanism of action of anti-HER2 monoclonal antibodies:scientific update on trastuzumab and 2C4[J].Adv Exp Med Biol,2003,532:253.
  • 10甄永苏.单克隆抗体药物治疗肿瘤的研究现状与展望[J].中国医学科学院学报,2000,22(1):9-13. 被引量:28

二级参考文献86

  • 1臧玮娜,臧瓅娜,姜雪莲,关建中.思维导图引导护理干预在肿瘤患者PET-CT检查中的应用效果[J].实用临床医药杂志,2020,24(7):80-83. 被引量:31
  • 2Plwa JL, Britta E ,Jayne L,et al Targeting Rat Anti-Mouse Transferrrin Receptor Monoclonal antibody through Blood -Brain Barrier in Mouse. [ J ]. J pharmacology and experiment therapeutics. 2000,292,1048-1057.
  • 3Remsen LG. Enhanced delivery improves the efficacy of a tumorspecific doxorubicin immunoconjugate in a human brain tumor xenograft model. [ J ]. Neurosurgery, 2000,46 ( 3 ) :704-709.
  • 4Sjogren HO, Isaksson Willner D ,et al. Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats [ J]. Cancer Res, 1997,57: 4530-4536.
  • 5Lode HN, Reisfeld RA, Handgretinger, Nicolaou, G Ga. et al. Targeted therapy with a novel enediyene antibiotic calicheamicin theta(I) 1 effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma. [ J ]. Cancer Res, 1998,58 : 2925-2928.
  • 6Katrin K, Wolfgang W, Jürgen E. et al. Targeted Therapy of Experimental Renal Cell Carcinoma with a Novel Conjugate of Monoclonal Antibody 138H11 and Calicheamicin I1 [J]. Cancer Res,2000,60 : 6089-6094.
  • 7Véronique and H. Uri Saragovi,Taxane-Antibody Conjugates Afford Potent Cytotoxicity, Enhanced Solubility, and Tumor Target Selectivity[J]. Cancer Res 2001 61 : 694-699.
  • 8Vogel CA, Galmiche MC, Buchegger F, Radioimmunotherapy and fractionated radiotherapy of human colon cancer liver metastases in nude mice [ J ]. Cancer Res, 1997,57 : 447 -453.
  • 9Robert T, Sally J. Aina, et al. Meyers Radioimmunotherapy with 111In/90Y-2IT-BAD-ml70 for Metastatic Prostate Cancer [ J ].Clin Cancer Res,2001,7 : 1561-1568.
  • 10Lee H. Jacy V, hepatotoxicity incancer patients receiving erb-38, a recombinant immunotoxi that targets the erb2 receptor [ J ]. Clin Cancer Res, 1999,5:2311-2315.

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