多发性硬化40例临床分析

A Clinical Analysis of 40 Cases of Multiple Sclerosis

目的探讨多发性硬化(MS)的临床特点、诊断及治疗。方法对40例MS患者的临床表现、辅助检查及预后等资料,结合文献进行回顾分析。结果MS以青壮年女性多见,以急性、亚急性起病为主;首发症状以视力障碍最常见(47.5%);大脑半球、视神经、脊髓受累的症状、体征最多见。MRI有助于早期诊断。甲基强的松龙的疗效好于地塞米松。结论本组MS临床特点不同于西方人,提高对MS临床症状、体征的认识,及时的MRI检查有助于早期诊断,激素治疗对大多数病人有效。

[Objective]To research the clinical features, diagnosis and treatment of multiple sclerosis （MS）. [Methods]Data on the clinical manifestations, auxiliary examinations and prognosis of 40 patients of MS were retrospectively analyzed with associated literatures. [Results]MS mainly invaded young and middleaged patients, with higher ratio in female than in male. MS was mostly acute or subacute in onset. Visual disturbance was the commonest first symptoms. Symptoms and signs of brain hemisphere, visual nerve and spinal cord injury were relatively common. MRI was helpful in early diagnosis. Methylprednisolone was more effective than dexamethason in treatment. [Conclusion]Features of MS in our country are different from those in the western countries. Improved recognization on clinical symptoms and signs , MRI examination in time would be helpful in early diagnosis. Treatment with Methylprednisolone or dexamethason is effective in most patients.