痹痛定胶囊对类风湿性关节炎患者辅助T细胞的影响

Effect of Bitongding Capsule on Helper T Cells in Rheumatoid Arthritis Patients

目的研究痹痛定胶囊对类风湿性关节炎(RA)患者辅助T细胞(Th1/Th2)的影响。方法通过酶联免疫法检测RA患者及健康人血清标本中γ干扰素(IFN-γ)和白细胞介素4(IL-4)的水平。结果RA患者组血清IFN-γ、IL-4水平和IFN-γ/IL-4比值显著高于健康对照组(P<0.01);经痹痛定胶囊治疗后RA患者IFN-γ、IL-4水平和IFN-γ/IL-4比值均明显下降(P<0.05或P<0.01)。结论痹痛定胶囊可通过抑制血清中IFN-γ和IL-4水平而抑制体液免疫和细胞免疫功能,提示痹痛定胶囊可调节RA患者体内Th1/Th2细胞的激活状况。

Objective To study the effect of Bitongding Capsule on helper T cells （Thl and Th2） in rheumatoid arthritis（RA） patients. Methods Euzymelinked immunosorbent assay was used to detect the serum level of interferon-γ（IFN-γ） and interleukin-4（IL- 4） in RA patients and healthy controllers. Results The serum level of IFN-γ,IL-4 and ratio of INF-γ and IL-4 in RA patient group increased significantly as compared with healthy control group（P〈0.01 ）,while decreased significantly after treatment （P〈0.05 or P 〈0.01）. Conclusion Bitongding Capsule can inhibit humoral and cellular immune functions by inhibiting the serum level of IFN-γ and IL-4,and regulate the activation of Thl and Th2 in RA patients.