颐脑解郁方对原发性抑郁症患者脑诱发电位的影响

Effect of Yi'nao Jieyu Formula on Brain Evoked Potential in Primary Depressive Illness Patients

目的观察原发性抑郁症患者脑诱发电位的空间分布特征及中药颐脑解郁方对其影响。方法采用病例对照研究和中药治疗组自身前后对照研究。采用脑诱发电位仪,记录60例原发性抑郁症患者(抑郁症组)和45名健康人(正常对照组)的脑干听觉诱发电位(BAEP)和视觉诱发电位(VEP),其中抑郁症组30例患者给予中药治疗6周后再次检测BAEP和VEP。结果抑郁症组患者BAEP与VEP各波潜伏期显著延长(P<0.05)治疗后VEP各波潜伏期均显著缩短(P<0.05),BAEP波潜伏期显著缩短(P<0.05),其余各项差异无显著性意义。结论抑郁症患者中枢神经系统对视觉、听觉刺激的应激能力下降;颐脑解郁方治疗原发性抑郁症疗效显著。

Objective To study the spatial distribution character of brain evoked potential （BEP） in primary depressive illness （PDI） patients and the effect of Yi＇nao Jieyu Formula. Methods Case control study and self-control study in Chinese herbal treatment group were conducted. Brain-stem auditory evoked potential （BAEP） and visual evoked potential （VEP） of 60 PDI patients and 45 healthy controllers were recorded by BEP apparatus made in Italy. BAEP and VEP of 30 patients of PDI group were detected again after taking Yi＇nao Jieyu Formula for 6 weeks. Results Latencies of whole waves in BAEP and VEP prolonged significantly in PDI group （P〈0.05） ,but latencies of whole waves in VEP and wave Ⅲ in BAEP shortened significantly after treatment（P〈0.05）. Conclusion The stress effect of central nervous system on visual and acoustic stimulus descends in PDI patients. Yi＇nao Jieyu Formula has obvious therapeutic effect on PDI.