Ki-67和CD44v5在卵巢癌中的表达和临床意义

Expression of ki-67 and CD44v5 in patients with ovarian cancer and its clinical significance

目的研究ki-67和CD44v5在卵巢癌中的表达及临床意义。方法用免疫组化sp法研究ki-67和CD44v5在40例卵巢癌手术切除标本及10例卵巢上皮良性肿瘤中的表达。结果40例卵巢癌中,ki-67和CD44v5的阳性表达率分别为77.5%和47.5%,远高于在卵巢上皮良性肿瘤中的表达30.0%和20.0%。且随着肿瘤病理分化程度的降低,ki-67、CD44v5阳性表达率均呈增高趋势;ki-67在卵巢腺癌中的阳性表达率明显高于透明细胞癌、内膜样癌(P<0.05);CD44v5的阳性表达率与表达强度伴淋巴转移者显著高于无淋巴转移者(P<0.01);两者呈正相关。结论ki-67和CD44v5在卵巢癌中的表达对卵巢癌的诊断、治疗方式的选择、手术范围的确定、及术后防治复发、化疗药物的应用,具有重要的指导意义。

Objective： To study the expressions of ki- 67 and CD44v5 in patients with ovarian cancer , and its clinical significance. Methods ： The expressions of ki - 67 and CD44v5 were determinded in 40 cases of ovarian cancer and 10 cases of normal ovarian tissue individual with immunohistochemical S - P method. Results ： The expression rate of ki - 67 and CD44v5 in 40 ovarian cancer samples was 77. 5% and 42. 5%, significantly higher than that in 10 cases of normal ovarian tissue individual （30. 0% and 20. 0% ）. In 40 ovarian cancer samples, The expression rate of ki -67 and CD44v5 both rise with the developing of ovarian cancer; The expression rate of ki - 67 in 31 ovarian cystadenocarcinoma significantly higher than that in other 9 ovarian cancer samples （ P 〈 0. 05 = ; The expression rate and intensity of CD44v5 in patients with tumorlymphoid metastasis were significantly higher than those without lymphoid metastasis （ P 〈 0. 01 =. Conclusion： It is helpful to measure the expression of ki -67 and CD44v5 in ovarian cancer for the diagnosis, treatment, deciding opration range, prevention and cure relapse after the opration and the amount of medicament.