INR在口服抗凝剂患者中的应用

Application of INR in the oral anticoagulation.

目的探讨国际标准化比率INR对口服抗凝剂患者的药物监测效果。方法用兔脑组织凝血活酶和进口人脑组织凝血活酶试剂分别检测49例口服抗凝剂患者组和50例正常对照组的凝血酶原时间PTS、凝血酶原时间比率PTR和国际标准化比率(INR)。结果两种试剂中以INR报告方式对药物所致的凝血因子缺乏监测最为标准。结论在门服抗凝剂的监控中,为克服组织凝血活酶试剂敏感性对PT结果的影响,应积极推行国际标准化比率(INR)报告方式。

Objective To study international normalization ratio（INR） for monitoring warfarin therapy. Methods Prothrombin times were measured in 49 orally antieoagulated patients and 50 normal served as controls using two different commercial thrnmboplastin reagents, a rabbit brain thrnmboplastin and a human brain thromboplastin, the results were reported with second, PTR or INR. Results Reporting prothrombin times is used to monitor warfarin therapy as an international normalized ratio （INR）. Conclusion IN the patients with warfarin therapy, as an international normalized ratio （INR） has been proposed as a way to eliminate interlaboratory differences in test results caused by the use of thromboplastins with different sensitivities.